miR-217 inhibits laryngeal cancer metastasis by repressing AEG-1 and PD-L1 expression

High incidences of laryngeal cancer have been reported recently. Increasing our understanding of the molecular mechanisms underlying this malignancy could reveal more effective approaches to treating laryngeal cancer patients and so improve their prognoses. In this study, we explored the biological...

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Published in:Oncotarget 2017-09, Vol.8 (37), p.62143-62153
Main Authors: Miao, Susheng, Mao, Xionghui, Zhao, Shu, Song, Kaibin, Xiang, Cheng, Lv, Yuanjing, Jiang, Huanyv, Wang, Lei, Li, Baojun, Yang, Xianguang, Yuan, Zhennan, Xiu, Cheng, Meng, Hongxue, Sun, Ji
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Language:English
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Research Paper
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Summary:High incidences of laryngeal cancer have been reported recently. Increasing our understanding of the molecular mechanisms underlying this malignancy could reveal more effective approaches to treating laryngeal cancer patients and so improve their prognoses. In this study, we explored the biological effects of miR-217 on laryngeal cancer. miR-217 potently inhibited multiple metastatic traits, including cell migration, invasion, proliferation, apoptosis, and EMT, as well as angiogensis. These effects were achieved through downregulation of the miR-217 target gene, AEG-1 and PD-L1. Clinical expression and animal model studies further confirmed our results. These findings provide new insight into the physiological effects of miR-217 in laryngeal cancer and its potential therapeutic use.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.19121