Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides

Seven analogs of the natural, α-helix peptides IsCT1 and IsCT2-found in the venom of scorpion -have been synthesized and tested to compare their antibacterial and hemolytic activity against natural peptides. In general, results show that increasing hydrophobicity by substituting positions 5 and 9 of...

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Bibliographic Details
Published in:Antibiotics (Basel) 2017-06, Vol.6 (3), p.13
Main Authors: de la Salud Bea, Roberto, Petraglia, Adam F, Ascuitto, Michael R, Buck, Quentin M
Format: Article
Language:English
Subjects:
Alanine
Analogs
Antibacterial activity
Bacteria
Cytotoxicity
Hydrophobicity
Leucine
Peptides
Toxicity
Toxicity testing
Valine
Venom
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Summary:Seven analogs of the natural, α-helix peptides IsCT1 and IsCT2-found in the venom of scorpion -have been synthesized and tested to compare their antibacterial and hemolytic activity against natural peptides. In general, results show that increasing hydrophobicity by substituting positions 5 and 9 of the sequences with alanine, valine, and leucine, enhances antibacterial activity. However, this also increases hemolytic activity. The analog with an increased net positive charge from +1 to +3 produces moderate bacterial growth inhibition but also has high hemolytic activity. On the other hand, the analog with a negative net charge (-1) has low antibacterial properties but also no cytotoxicity under the tested conditions, a similar result was found for five of the seven studied analogs.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics6030013