Tenascin-C and fibronectin in normal esophageal mucosa, Barrett's esophagus, dysplasia and adenocarcinoma

Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is poorly known. The aim of this study was to evaluate the expression of tenascin-C and fibronectin in esophag...

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Published in:Oncotarget 2017-09, Vol.8 (40), p.66865-66877
Main Authors: Leppänen, Joni, Bogdanoff, Sara, Lehenkari, Petri P, Saarnio, Juha, Kauppila, Joonas H, Karttunen, Tuomo J, Huhta, Heikki, Helminen, Olli
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Language:English
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Summary:Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is poorly known. The aim of this study was to evaluate the expression of tenascin-C and fibronectin in esophageal adenocarcinoma and its precursor stages. Stromal tenascin-C and fibronectin expression were found in all evaluated lesion types. Expression of both molecules increased from gastric metaplasia towards adenocarcinoma (p
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.19196