MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A

Lactate dehydrogenase A (LDHA) is overexpressed in various cancers. We investigated LDHA expression and function in bladder cancer. We demonstrate that LDHA is up-regulated in bladder cancer cells and promotes proliferation, invasion, and glycolysis. Additionally, we found that microRNA (miR)-200c d...

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Published in:Oncotarget 2017-09, Vol.8 (40), p.67663-67669
Main Authors: Yuan, Daozhang, Zheng, Shunsheng, Wang, Liyan, Li, Jing, Yang, Jianan, Wang, Bin, Chen, Xiong, Zhang, Xiaobo
Format: Article
Language:English
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Research Paper
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Summary:Lactate dehydrogenase A (LDHA) is overexpressed in various cancers. We investigated LDHA expression and function in bladder cancer. We demonstrate that LDHA is up-regulated in bladder cancer cells and promotes proliferation, invasion, and glycolysis. Additionally, we found that microRNA (miR)-200c directly targets LDHA in bladder cancer cells. Ectopic expression of miR-200c inhibited LDHA-induced glycolysis, cell proliferation, and invasion. Thus, targeting LDHA through miR-200c is a potential therapeutic strategy in bladder cancer.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.18801