Pattern Recognition Analysis Reveals Unique Contrast Sensitivity Isocontours Using Static Perimetry Thresholds Across the Visual Field

• Published in: Investigative ophthalmology & visual science 2017-09, Vol.58 (11), p.4863-4876
• Main Authors: Phu, Jack, Khuu, Sieu K, Nivison-Smith, Lisa, Zangerl, Barbara, Choi, Agnes Yiu Jeung, Jones, Bryan W, Pfeiffer, Rebecca L, Marc, Robert E, Kalloniatis, Michael
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Aged; Aging - physiology; Cluster Analysis; Contrast Sensitivity - physiology; Glaucoma - diagnosis; Humans; Male; Middle Aged; Pattern Recognition, Visual - physiology; Regression Analysis; Sensory Thresholds - physiology; Visual Field Tests - methods; Visual Fields - physiology; Visual Psychophysics and Physiological Optics
• ISSN: 1552-5783; 0146-0404; 1552-5783
• DOI: 10.1167/iovs.17-22371

To determine the locus of test locations that exhibit statistically similar age-related decline in sensitivity to light increments and age-corrected contrast sensitivity isocontours (CSIs) across the central visual field (VF). We compared these CSIs with test point clusters used by the Glaucoma Hemifield Test (GHT). Sixty healthy observers underwent testing on the Humphrey Field Analyzer 30-2 test grid using Goldmann (G) stimulus sizes I-V. Age-correction factors for GI-V were determined using linear regression analysis. Pattern recognition analysis was used to cluster test locations across the VF exhibiting equal age-related sensitivity decline (age-related CSIs), and points of equal age-corrected sensitivity (age-corrected CSIs) for GI-V. There was a small but significant test size-dependent sensitivity decline with age, with smaller stimuli declining more rapidly. Age-related decline in sensitivity was more rapid in the periphery. A greater number of unique age-related CSIs was revealed when using smaller stimuli, particularly in the mid-periphery. Cluster analysis of age-corrected sensitivity thresholds revealed unique CSIs for GI-V, with smaller stimuli having a greater number of unique clusters. Zones examined by the GHT consisted of test locations that did not necessarily belong to the same CSI, particularly in the periphery. Cluster analysis reveals statistically significant groups of test locations within the 30-2 test grid exhibiting the same age-related decline. CSIs facilitate pooling of sensitivities to reduce the variability of individual test locations. These CSIs could guide future structure-function and alternate hemifield asymmetry analyses by comparing matched areas of similar sensitivity signatures.