Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro

Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis. This study investigates the role of macrophage-derived, caspase-1-dependent int...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2017-10, Vol.66 (10), p.1287-1294
Main Authors: Storr, Sarah J., Safuan, Sabreena, Ahmad, Narmeen, El-Refaee, Mohammed, Jackson, Andrew M., Martin, Stewart G.
Format: Article
Language:English
Subjects:
Angiogenesis
Blood
Breast cancer
Cancer Research
Caspase
Caspase-1
Cell adhesion
Cell adhesion & migration
Conditioning
Cytokines
Endothelial cells
Endothelium
IL-1β
Immunology
Leukocyte migration
Macrophages
Medicine
Medicine & Public Health
Oncology
Original
Original Article
Stimulation
Tumor cell lines
Tumor microenvironment
Tumorigenesis
Tumors
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Summary:Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis. This study investigates the role of macrophage-derived, caspase-1-dependent interleukin-1beta (IL-1β) in an in vitro model of LVI. IL-1β significantly augmented the adhesion and transmigration of breast cancer cell lines MCF7 and MDA-MB-231 across endothelial cell barriers. MDA-MB-231 and MCF7 showed a higher percentage of adhesion to lymphatic endothelial cells than blood endothelial cells following endothelial cell IL-1β stimulation ( P  
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-017-2020-0