Is the Extracellular Impedance High and Non-resistive in Cerebral Cortex?

A recent commentary to Biophysical Journal criticized a previous study published in the same journal by Gomes et al. in 2016, and an alternative interpretation of the measurements was proposed. We reply here to these criticisms and provide some additional clarification, in particular, about a possib...

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Bibliographic Details
Published in:Biophysical journal 2017-10, Vol.113 (7), p.1639-1642
Main Authors: Bédard, Claude, Destexhe, Alain
Format: Article
Language:English
Subjects:
Biophysics
Brain
Cerebral Cortex
Cognitive Sciences
Comments to the Editors
Conductivity
Electric Impedance
Electrodes
Impedance
Life Sciences
Neurobiology
Neurons and Cognition
Psychology and behavior
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Summary:A recent commentary to Biophysical Journal criticized a previous study published in the same journal by Gomes et al. in 2016, and an alternative interpretation of the measurements was proposed. We reply here to these criticisms and provide some additional clarification, in particular, about a possible misinterpretation of the electrical circuit corresponding to these experiments. We suggest that, indeed, the extracellular impedance in cerebral cortex could be high and non-resistive, and we propose further experiments to settle this issue.
ISSN:0006-3495
1542-0086
DOI:10.1016/j.bpj.2017.08.021