The value of APACHE II in predicting mortality after paraquat poisoning in Chinese and Korean population: A systematic review and meta-analysis

The Acute Physiology and Chronic Health Evaluation II (APACHE II) score is used to determine disease severity and predict outcomes in critically ill patients. However, the prognostic significance of APACHE after acute paraquat (PQ) poisoning remains unclear. The meta-analysis was aimed to study the...

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Bibliographic Details
Published in:Medicine (Baltimore) 2017-07, Vol.96 (30), p.e6838-e6838
Main Authors: Huang, Jianshu, Xuan, Dandan, Li, Xiuju, Ma, Li, Zhou, Yuanling, Zou, Hejian
Format: Article
Language:English
Subjects:
APACHE
China
Herbicides - poisoning
Humans
Mortality
Paraquat - poisoning
Prognosis
Republic of Korea
Systematic Review and Meta-Analysis
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Summary:The Acute Physiology and Chronic Health Evaluation II (APACHE II) score is used to determine disease severity and predict outcomes in critically ill patients. However, the prognostic significance of APACHE after acute paraquat (PQ) poisoning remains unclear. The meta-analysis was aimed to study the value of APACHE II in predicting mortality in PQ-exposed Chinese and Korean patients. Databases that included PubMed, Embase, Cochrane Library, and the Chinese National Knowledge Infrastructure were searched through August 2016. Studies using APACHE II to predict mortality in PQ-poisoned patients were selected. The odds ratio and weighted mean difference (WMD) were used to pool binary and continuous data. Additionally, we aggregated sensitivity, specificity, and other measures of accuracy. Statistical analyses were made using the Stata V.13.0 software. This study included 29 studies, and 25 studies evaluated APACHE II scores on admission. Pooled data showed that survivors had significantly lower total scores than nonsurvivors (WMD = -7.29, and I = 98.2%, both P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000006838