Promising significance of the association of miR-204-5p expression with clinicopathological features of hepatocellular carcinoma

Decreased level of miR-204-5p has been documented in various malignancies. However, the expression and clinical significance of miR-204-5p in hepatocellular carcinoma has not been investigated. The aim of this study is to examine the relationship between miR-204-5p expression and clinicopathological...

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Published in:Medicine (Baltimore) 2017-07, Vol.96 (30), p.e7545-e7545
Main Authors: Luo, Yi-Huan, Tang, Wei, Zhang, Xin, Tan, Zhong, Guo, Wen-Liang, Zhao, Na, Pang, Si-Min, Dang, Yi-Wu, Rong, Min-Hua, Cao, Ji
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Disease Progression
Humans
Liver - metabolism
Liver - pathology
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
MicroRNAs - metabolism
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Observational Study
Survival Analysis
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Summary:Decreased level of miR-204-5p has been documented in various malignancies. However, the expression and clinical significance of miR-204-5p in hepatocellular carcinoma has not been investigated. The aim of this study is to examine the relationship between miR-204-5p expression and clinicopathological features in hepatocellular carcinoma (HCC) as well as to predict the relevant signaling pathways. The miR-204-5p expression level was detected in HCC and in matched paraneoplastic liver from 95 formalin-fixed paraffin-embedded tissues by the real-time reverse transcription polymerized chain reaction (qRT-PCR). The association of miR-204-5p expression with clinicopathological features as well as the prognosis of HCC was examined. Public data portals including the Gene Expression Omnibus and The Cancer Genome Atlas were used to retrieve the HCC-related data in order to perform a comprehensive meta-analysis. Meanwhile, protein-protein interaction (PPI) and enrichment analyses were performed using predicted target genes. The relative expression of miR-204-5p was remarkably reduced in HCC than that in paraneoplastic hepatic tissues. In HCC, the miR-204-5p expression was downregulated in the metastasis, vasoinvasion, and advanced stage (III and IV) subgroups compared with their counterparts. Furthermore, the meta-analysis based on qRT-PCR data demonstrated that miR-204-5p was markedly downregulated in HCC with a standardized mean difference of -5.19 (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000007545