The impact of host's genetic susceptibility on Helicobacter pylori infection in children

The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was p...

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Published in:Medicine (Baltimore) 2017-07, Vol.96 (30), p.e7612-e7612
Main Authors: Mărginean, Maria Oana, Mărginean, Cristina Oana, Meliţ, Lorena Elena, Voidăzan, Septimiu, Moldovan, Valeriu, Bănescu, Claudia
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Cross-Sectional Studies
Female
Genetic Predisposition to Disease
Genotype
Helicobacter Infections - epidemiology
Helicobacter Infections - genetics
Helicobacter Infections - immunology
Helicobacter pylori
Humans
Incidence
Interleukin-6 - genetics
Logistic Models
Male
Multivariate Analysis
Observational Study
Peptidyl-Dipeptidase A - genetics
Prospective Studies
Romania
Tertiary Care Centers
Tumor Necrosis Factor-alpha - genetics
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Summary:The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania. Children were assessed clinically, endoscopically, histopathologically, and genetically.In our study, we found that the presence of the CT and CT+TT genotypes of IL-6 190C/T (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000007612