SOX7 promotes the maintenance and proliferation of B cell precursor acute lymphoblastic cells

B cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most frequent type of cancer in children. Despite progresses in curative treatment, intensive chemotherapy regimens still cause life threatening complications. A better understanding of the molecular mechanisms underlying the emergence a...

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Bibliographic Details
Published in:Oncotarget 2017-09, Vol.8 (39), p.64974-64983
Main Authors: Cuvertino, Sara, Filiciotto, Genny, Masurekar, Ashish, Saha, Vaskar, Lacaud, Georges, Kouskoff, Valerie
Format: Article
Language:English
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Research Paper
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Summary:B cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most frequent type of cancer in children. Despite progresses in curative treatment, intensive chemotherapy regimens still cause life threatening complications. A better understanding of the molecular mechanisms underlying the emergence and maintenance of BCP-ALL is fundamental for the development of novel therapies. Here, we establish that is frequently and specifically expressed in BCP-ALL and that the expression of this transcription factor does not correlate with any specific cytogenetic abnormalities. Using human leukemia model systems, we establish that the down-regulation of in BCP-ALL causes a significant decrease in proliferation and clonogenicity that correlates with a delay in leukemia initiation and burden . Overall, these results identify a novel and important functional role for the transcription factor SOX7 in promoting the maintenance of BCP-ALL.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.10472