Diffusion-weighted imaging for assessment of synovial inflammation in juvenile idiopathic arthritis: a promising imaging biomarker as an alternative to gadolinium-based contrast agents

• Published in: European radiology 2017-11, Vol.27 (11), p.4889-4899
• Main Authors: Barendregt, Anouk M., van Gulik, E. Charlotte, Lavini, Cristina, Nusman, Charlotte M., van den Berg, J. Merlijn, Schonenberg-Meinema, Dieneke, Dolman, Koert M., Kuijpers, Taco W., Hemke, Robert, Maas, Mario
• Format: Article
• Language: English
• Subjects: Adolescent; Arthritis; Arthritis, Juvenile - diagnostic imaging; Biomarkers; Child; Confidence intervals; Contrast agents; Contrast Media - administration & dosage; Correlation analysis; Cross-Sectional Studies; Diagnostic Radiology; Diffusion coefficient; Diffusion Magnetic Resonance Imaging - methods; Female; Gadolinium; Gadolinium - administration & dosage; Humans; Imaging; Inflammation; Internal Medicine; Interventional Radiology; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Musculoskeletal; Neuroradiology; Patients; Radiology; Synovitis; Synovitis - diagnostic imaging; Synovium; Ultrasound
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-017-4876-y

Objectives To compare dynamic-contrast-enhanced MRI (DCE) and diffusion-weighted imaging (DWI) in quantifying synovial inflammation in juvenile idiopathic arthritis (JIA). Methods Regions of interest (ROI) were drawn in the synovium of JIA patients on T1 DCE and T2 DWI, followed by extraction of the maximum enhancement (ME), maximum initial slope (MIS), time to peak (TTP), % of different time intensity curve shapes (TIC) and apparent diffusion coefficient (ADC) of the ROIs. Mann-Whitney-U test was used for comparing parameters between MRI-active and -inactive patients (defined by the juvenile arthritis MRI scoring system). Spearman’s rank was used to analyse the correlation between DCE and DWI. Results Thirty-five JIA patients (18 MRI active and 17 MRI inactive) were included. Median age was 13.1 years and 71% were female. ME, MIS, TTP, % TIC 5 and ADC were significantly different in MRI-active versus MRI-inactive JIA with median ADC 1.49 × 10 -3 mm 2 /s in MRI-active and 1.25 × 10 -3 mm 2 /s in MRI-inactive JIA, p = 0.001, 95% confidence interval of difference in medians =0.11-0.53 × 10 -3 mm 2 /s. ADC correlated to ME, MIS and TIC 5 shapes ( r = 0.62, r = 0.45, r = -0.51, respectively, all p < 0.05). Conclusions Similar to DCE parameters, DWI-derived ADC is significantly different in MRI-active JIA as compared to MRI-inactive JIA. The non-invasiveness of DWI combined with its possibility to detect synovial inflammation shows the potential of DWI. Key Points • MRI can quantify: dynamic contrast - enhanced and diffusion - weighted MRI can quantify synovitis • Both DWI and DCE can differentiate active from inactive JIA • The DWI - derived apparent diffusion coefficient ( ADC ) is higher in active JIA • DWI is non - invasive and thus safer and more patient - friendly • DWI is a potentially powerful and non - invasive imaging biomarker for JIA