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Comparative accuracy of mammography and ultrasound in women with breast symptoms according to age and breast density
Breast cancer is the most common cancer and the second most common cause of death from cancer in women.The aim of this studywas to determine which is more accurate imaging test mammography or ultrasound for diagnosis of breast cancer based on the women's age and breast density. We examined 546...
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Published in: | Biomolecules & biomedicine 2009-05, Vol.9 (2), p.131-136 |
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description | Breast cancer is the most common cancer and the second most common cause of death from cancer in women.The aim of this studywas to determine which is more accurate imaging test mammography or ultrasound for diagnosis of breast cancer based on the women's age and breast density. We examined 546 patients with breast symptoms, by clinical breast examination, mammography and ultrasound. A total of 546 breast lesions were examined by histopathology analyses. Histopathology results revealed the presence of 259 invasive cancers, and 287 benign lesions. Sensitivity varied significantly with age and breast density. In the 259 women who had both tests, ultrasound had a higher sensitivity than mammography in women younger than 45 years, whereas mammography had a higher sensitivity than ultrasound in women older than 60 years. The sensitivity according to age was 52,1% for mammography and 72,6% for ultrasound. The specificity according to age was 88, 5% for ultrasound and 73, 9% for mammography. Comparing the sensitivity of mammography and ultrasound according to the breast density indicates that mammographic sensitivity was 82,2% among women with predominantly fatty breast, but 23.7% in women with heterogeneous dense breasts, with the increase of fibro glandular density the level of sensitivity with mammography decreases, while ultrasonographic sensitivity was 71,1% among women with predominantly fatty breast and 57,0% for heterogeneous dense breasts. Our data indicate that sensitivity and specificity of ultrasound was statistically significantly greater than mammography in patients with breast symptoms for the detection of breast cancer and benign lesions particularly in dense breast and in young women. |
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We examined 546 patients with breast symptoms, by clinical breast examination, mammography and ultrasound. A total of 546 breast lesions were examined by histopathology analyses. Histopathology results revealed the presence of 259 invasive cancers, and 287 benign lesions. Sensitivity varied significantly with age and breast density. In the 259 women who had both tests, ultrasound had a higher sensitivity than mammography in women younger than 45 years, whereas mammography had a higher sensitivity than ultrasound in women older than 60 years. The sensitivity according to age was 52,1% for mammography and 72,6% for ultrasound. The specificity according to age was 88, 5% for ultrasound and 73, 9% for mammography. Comparing the sensitivity of mammography and ultrasound according to the breast density indicates that mammographic sensitivity was 82,2% among women with predominantly fatty breast, but 23.7% in women with heterogeneous dense breasts, with the increase of fibro glandular density the level of sensitivity with mammography decreases, while ultrasonographic sensitivity was 71,1% among women with predominantly fatty breast and 57,0% for heterogeneous dense breasts. Our data indicate that sensitivity and specificity of ultrasound was statistically significantly greater than mammography in patients with breast symptoms for the detection of breast cancer and benign lesions particularly in dense breast and in young women.</description><identifier>ISSN: 1512-8601</identifier><identifier>ISSN: 2831-0896</identifier><identifier>EISSN: 1840-4812</identifier><identifier>EISSN: 2831-090X</identifier><identifier>DOI: 10.17305/bjbms.2009.2832</identifier><identifier>PMID: 19485945</identifier><language>eng</language><publisher>Bosnia and Herzegovina: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina</publisher><subject>Adult ; Age Factors ; Aged ; Breast - pathology ; breast lesions ; Breast Neoplasms - diagnosis ; Breast Neoplasms - diagnostic imaging ; diagnostic methods ; Female ; Humans ; Mammography ; Middle Aged ; Sensitivity and Specificity ; Ultrasonography, Mammary ; ultrasound</subject><ispartof>Biomolecules & biomedicine, 2009-05, Vol.9 (2), p.131-136</ispartof><rights>Copyright: © 2009 ABMSFBIH 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-da6662c1f9469be62362917515cad2642a8b317ee5d3a65cf1558e16bc5c9cbe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638217/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638217/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19485945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Devolli-Disha, Emine</creatorcontrib><creatorcontrib>Manxhuka-Kërliu, Suzana</creatorcontrib><creatorcontrib>Ymeri, Halit</creatorcontrib><creatorcontrib>Kutllovci, Arben</creatorcontrib><title>Comparative accuracy of mammography and ultrasound in women with breast symptoms according to age and breast density</title><title>Biomolecules & biomedicine</title><addtitle>Bosn J Basic Med Sci</addtitle><description>Breast cancer is the most common cancer and the second most common cause of death from cancer in women.The aim of this studywas to determine which is more accurate imaging test mammography or ultrasound for diagnosis of breast cancer based on the women's age and breast density. We examined 546 patients with breast symptoms, by clinical breast examination, mammography and ultrasound. A total of 546 breast lesions were examined by histopathology analyses. Histopathology results revealed the presence of 259 invasive cancers, and 287 benign lesions. Sensitivity varied significantly with age and breast density. In the 259 women who had both tests, ultrasound had a higher sensitivity than mammography in women younger than 45 years, whereas mammography had a higher sensitivity than ultrasound in women older than 60 years. The sensitivity according to age was 52,1% for mammography and 72,6% for ultrasound. The specificity according to age was 88, 5% for ultrasound and 73, 9% for mammography. Comparing the sensitivity of mammography and ultrasound according to the breast density indicates that mammographic sensitivity was 82,2% among women with predominantly fatty breast, but 23.7% in women with heterogeneous dense breasts, with the increase of fibro glandular density the level of sensitivity with mammography decreases, while ultrasonographic sensitivity was 71,1% among women with predominantly fatty breast and 57,0% for heterogeneous dense breasts. Our data indicate that sensitivity and specificity of ultrasound was statistically significantly greater than mammography in patients with breast symptoms for the detection of breast cancer and benign lesions particularly in dense breast and in young women.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Breast - pathology</subject><subject>breast lesions</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>diagnostic methods</subject><subject>Female</subject><subject>Humans</subject><subject>Mammography</subject><subject>Middle Aged</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonography, Mammary</subject><subject>ultrasound</subject><issn>1512-8601</issn><issn>2831-0896</issn><issn>1840-4812</issn><issn>2831-090X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkUtv1DAURiMEou3AnhXKil0Gv-NskNAIaKVKbGBtXT-S8SiOB9spyr8n8xDQjX1lf_dcy6eq3mG0xS1F_KM-6JC3BKFuSyQlL6pbLBlqmMTk5VpzTBopEL6p7nI-ICQ6Ktnr6gZ3TPKO8duq7GI4QoLin1wNxswJzFLHvg4QQhwSHPdLDZOt57EkyHFeSz_Vv2Nw6-rLvtbJQS51XsKxxJBPkJisn4a6xBoGd-6-hqybsi_Lm-pVD2N2b6_7pvr59cuP3X3z-P3bw-7zY2MYlqWxIIQgBvcdE512glBBOtxyzA1YIhgBqSluneOWguCmx5xLh4U23HRGO7qpHi5cG-GgjskHSIuK4NX5IKZBQSrejE7xllitOaEaM9Y6BsKuIxHTWlDZa7SyPl1Yx1kHZ42b1v8Yn0Gf30x-r4b4pPgKIKutTfXhCkjx1-xyUcFn48YRJhfnrERLcYcQW4PoEjQp5pxc_3cIRuqsXZ21q5N2ddK-trz__3H_Gq6e6R9Qha1L</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Devolli-Disha, Emine</creator><creator>Manxhuka-Kërliu, Suzana</creator><creator>Ymeri, Halit</creator><creator>Kutllovci, Arben</creator><general>Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20090501</creationdate><title>Comparative accuracy of mammography and ultrasound in women with breast symptoms according to age and breast density</title><author>Devolli-Disha, Emine ; Manxhuka-Kërliu, Suzana ; Ymeri, Halit ; Kutllovci, Arben</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-da6662c1f9469be62362917515cad2642a8b317ee5d3a65cf1558e16bc5c9cbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Breast - pathology</topic><topic>breast lesions</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>diagnostic methods</topic><topic>Female</topic><topic>Humans</topic><topic>Mammography</topic><topic>Middle Aged</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonography, Mammary</topic><topic>ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devolli-Disha, Emine</creatorcontrib><creatorcontrib>Manxhuka-Kërliu, Suzana</creatorcontrib><creatorcontrib>Ymeri, Halit</creatorcontrib><creatorcontrib>Kutllovci, Arben</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Biomolecules & biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devolli-Disha, Emine</au><au>Manxhuka-Kërliu, Suzana</au><au>Ymeri, Halit</au><au>Kutllovci, Arben</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative accuracy of mammography and ultrasound in women with breast symptoms according to age and breast density</atitle><jtitle>Biomolecules & biomedicine</jtitle><addtitle>Bosn J Basic Med Sci</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>9</volume><issue>2</issue><spage>131</spage><epage>136</epage><pages>131-136</pages><issn>1512-8601</issn><issn>2831-0896</issn><eissn>1840-4812</eissn><eissn>2831-090X</eissn><abstract>Breast cancer is the most common cancer and the second most common cause of death from cancer in women.The aim of this studywas to determine which is more accurate imaging test mammography or ultrasound for diagnosis of breast cancer based on the women's age and breast density. 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Comparing the sensitivity of mammography and ultrasound according to the breast density indicates that mammographic sensitivity was 82,2% among women with predominantly fatty breast, but 23.7% in women with heterogeneous dense breasts, with the increase of fibro glandular density the level of sensitivity with mammography decreases, while ultrasonographic sensitivity was 71,1% among women with predominantly fatty breast and 57,0% for heterogeneous dense breasts. Our data indicate that sensitivity and specificity of ultrasound was statistically significantly greater than mammography in patients with breast symptoms for the detection of breast cancer and benign lesions particularly in dense breast and in young women.</abstract><cop>Bosnia and Herzegovina</cop><pub>Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina</pub><pmid>19485945</pmid><doi>10.17305/bjbms.2009.2832</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Age Factors Aged Breast - pathology breast lesions Breast Neoplasms - diagnosis Breast Neoplasms - diagnostic imaging diagnostic methods Female Humans Mammography Middle Aged Sensitivity and Specificity Ultrasonography, Mammary ultrasound |
title | Comparative accuracy of mammography and ultrasound in women with breast symptoms according to age and breast density |
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