Virus-based nanoparticles as platform technologies for modern vaccines

Nanoscale engineering is revolutionizing the development of vaccines and immunotherapies. Viruses have played a key role in this field because they can function as prefabricated nanoscaffolds with unique properties that are easy to modify. Viruses are immunogenic via multiple pathways, and antigens...

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Bibliographic Details
Published in:Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2016-07, Vol.8 (4), p.554-578
Main Authors: Lee, Karin L., Twyman, Richard M., Fiering, Steven, Steinmetz, Nicole F.
Format: Article
Language:English
Subjects:
Addictions
Animals
Antigens
Cancer
Chronic illnesses
Drug Delivery Systems - methods
Humans
Immunogenicity
Immunotherapy
Infectious diseases
Mice
Nanomaterials
Nanomedicine - methods
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Nanotechnology
Prefabrication
Tumors
Vaccination
Vaccines
Virion - chemistry
Virion - ultrastructure
Viruses
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Summary:Nanoscale engineering is revolutionizing the development of vaccines and immunotherapies. Viruses have played a key role in this field because they can function as prefabricated nanoscaffolds with unique properties that are easy to modify. Viruses are immunogenic via multiple pathways, and antigens displayed naturally or by engineering on the surface can be used to create vaccines against the cognate virus, other pathogens, specific molecules or cellular targets such as tumors. This review focuses on the development of virus‐based nanoparticle systems as vaccines indicated for the prevention or treatment of infectious diseases, chronic diseases, cancer, and addiction. WIREs Nanomed Nanobiotechnol 2016, 8:554–578. doi: 10.1002/wnan.1383 This article is categorized under: Biology-Inspired Nanomaterials > Protein and Virus-Based Structures
ISSN:1939-5116
1939-0041
DOI:10.1002/wnan.1383