Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value?

• Published in: World journal of nuclear medicine 2017-10, Vol.16 (4), p.275-280
• Main Authors: Köroglu, Reyhan, Köksal, İsmail, Şimşek, Fikri, Gezer, Fatma, Kekilli, Ersoy, Ünal, Bülent
• Format: Article
• Language: English
• Subjects: Biopsy; Breast cancer; Cancer; Chemotherapy; Computed tomography; Correlation; Emission analysis; Gene amplification; Mammography; Mathematical analysis; Medical imaging; Medical prognosis; Medical schools; Metabolism; Metastasis; Nuclear medicine; Original; Original article; Parameters; Patients; Positron emission; Positron emission tomography; Prognosis; Quantitative analysis; Studies; Tumors; Ultrasonic imaging
• ISSN: 1450-1147; 1607-3312
• DOI: 10.4103/1450-1147.215485

It was aimed to investigate the correlation between maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and retention index (RI), which represents the quantitative evaluation of the uptake of 18 F-fluoro-2-deoxy-D-glucose ( 18 F-FDG) used in positron emission tomography (PET) and clinicopathologic as well as biologic prognostic factors. Forty-one women with breast cancer who were histopathologically diagnosed were included in this study. Neoadjuvant chemotherapy was applied to all patients before PET/computed tomography (CT). After FDG injection, PET/CT screening was applied within the 1 st h (PET-1) and in the 2 nd h (PET-2). SUVmax, SUVmean, SUVmax RI, and SUVmean RI of every image were calculated qualitatively and semiquantitatively. The correlation between quantitative and semiquantitative PET parameters and biologic as well as clinicopathologic prognosis factors was evaluated. Statistically, significant positive correlation was found between lymph nodes (LNs), which were evaluated by clinical picture, clinical stage as well as histopathologically and quantitative PET parameters (SUVmax1, SUVmax2, , RImax, SUVmean1, SUVmean2, RImean) (P < 0.05). While statistically significant correlation with RImax was detected only by LN (histopathological), correlations with RImean were detected by clinical picture, clinical stage, metabolic stage, and LN (histopathological). Statistically, significant correlation was found between RImax and estrogen receptor in patients who were histopathologically diagnosed with invasive ductal carcinoma (n = 34) (P < 0.05). We detected correlations between biologic and clinicopathologic prognostic factors and SUVmax as well as SUVmean values in breast carcinoma. SUVmean values may provide important knowledge when the correlation between prognostic factors and PET parameters is investigated even if they are not used routinely.