All-treatment array of hepatocellular carcinoma from initial diagnosis to death: observation of cumulative treatments

Purpose In clinical practice, most patients with hepatocellular carcinoma require subsequent treatments for remaining, progressing, or recurring tumors. We investigated all-treatment array and outcomes in an HCC cohort from initial diagnosis to death. Methods We enrolled 1687 consecutive patients wi...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2017-11, Vol.143 (11), p.2327-2339
Main Authors: Moon, Hae, Choi, Ji Eun, Lee, In Joon, Kim, Tae Hyun, Kim, Seong Hoon, Ko, Young Hwan, Kim, Hyun Boem, Nam, Byung-Ho, Park, Joong-Won
Format: Article
Language:English
Subjects:
Aged
Cancer Research
Cancer therapies
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - therapy
Clinical outcomes
Cohort analysis
Combined Modality Therapy
Diagnosis
Female
Follow-Up Studies
Hematology
Hepatocellular carcinoma
Humans
Internal Medicine
Liver cancer
Liver Neoplasms - diagnosis
Liver Neoplasms - mortality
Liver Neoplasms - therapy
Male
Medical treatment
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - therapy
Neoplasm Staging
Oncology
Original Article – Clinical Oncology
Original – Clinical Oncology
Republic of Korea
Retrospective Studies
Survival Rate
Transplantation
Treatment Outcome
Tumors
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Summary:Purpose In clinical practice, most patients with hepatocellular carcinoma require subsequent treatments for remaining, progressing, or recurring tumors. We investigated all-treatment array and outcomes in an HCC cohort from initial diagnosis to death. Methods We enrolled 1687 consecutive patients with HCC who underwent initial diagnosis and treatment at the National Cancer Center, Korea, from January 2004 to December 2009. Results In total, 1357 patients (80.4%) showed RPRTs during median 20.4-month follow-up. Initial transplantation resulted in the least rate (32.3%) of RPRTs. Median treatment frequency was 3.0 times (range 1–20) and 382 patients (27.3%) received treatments ≥6 times. The median treatment frequency was different based on four factors ( p  
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-017-2480-9