Epstein-Barr Virus LMP1-Mediated Oncogenicity

Epstein-Barr virus latent membrane protein 1 (LMP1) is expressed in multiple human malignancies, including nasopharyngeal carcinoma and Hodgkin and immunosuppression-associated lymphomas. LMP1 mimics CD40 signaling to activate multiple growth and survival pathways, in particular, NF-κB. LMP1 has cri...

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Bibliographic Details
Published in:Journal of virology 2017-11, Vol.91 (21)
Main Authors: Wang, Liang Wei, Jiang, Sizun, Gewurz, Benjamin E
Format: Article
Language:English
Subjects:
Animals
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Gem
Humans
Neoplasms - metabolism
Neoplasms - pathology
Viral Matrix Proteins - metabolism
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Summary:Epstein-Barr virus latent membrane protein 1 (LMP1) is expressed in multiple human malignancies, including nasopharyngeal carcinoma and Hodgkin and immunosuppression-associated lymphomas. LMP1 mimics CD40 signaling to activate multiple growth and survival pathways, in particular, NF-κB. LMP1 has critical roles in Epstein-Barr virus (EBV)-driven B-cell transformation, and its expression causes fatal lymphoproliferative disease in immunosuppressed mice. Here, we review recent developments in studies of LMP1 signaling, LMP1-induced host dependency factors, mouse models of LMP1 lymphomagenesis, and anti-LMP1 immunotherapy approaches.
ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.01718-16