Different effection of p.1125Val>Ala and rs11954856 in APC on Wnt signaling pathway

• Published in: Oncotarget 2017-09, Vol.8 (41), p.70854-70864
• Main Authors: Li, Fei-Feng, Zhao, Zhi-Xun, Yan, Peng, Wang, Song, Liu, Zheng, Zhang, Qiong, Zhang, Xiao-Ning, Sun, Chang-Hao, Wang, Xi-Shan, Wang, Gui-Yu, Liu, Shu-Lin
• Format: Article
• Language: English
• Subjects: Research Paper
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.20106

Colorectal cancer (CRC) is among the most common and fatal forms of solid tumors worldwide and more than two thirds of CRC and adenomas patients have gene mutations. APC is a key regulator in the Wnt/β-catenin signaling pathway but its roles in CRC remains to be elucidated. In this study, we compared genes between CRC patients and controls to determine possible associations of nucleotide changes in the gene with the pathways involved in CRC pathogenesis. All participants received physical and enteroscopic examinations. The gene was sequenced for 300 Chinese Han CRC patients and 411 normal controls, and the expression levels of genes in the signaling pathway were analyzed using Western Blotting. Statistical analyses were conducted using SPSS (version 19.0) software. We found that rs11954856 in the gene was associated with colorectal cancer and could increase the expression levels of , , , and genes in the pathway in the CRC patients, demonstrating the involvement of APC in the pathological processes leading to CRC.