Circulating myeloid-derived suppressor cells increase in patients undergoing neo-adjuvant chemotherapy for breast cancer

This study sought to evaluate whether myeloid-derived suppressor cells (MDSC) could be affected by chemotherapy and correlate with pathologic complete response (pCR) in breast cancer patients receiving neo-adjuvant chemotherapy. Peripheral blood levels of granulocytic (G-MDSC) and monocytic (M-MDSC)...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2017-11, Vol.66 (11), p.1437-1447
Main Authors: Wesolowski, Robert, Duggan, Megan C., Stiff, Andrew, Markowitz, Joseph, Trikha, Prashant, Levine, Kala M., Schoenfield, Lynn, Abdel-Rasoul, Mahmoud, Layman, Rachel, Ramaswamy, Bhuvaneswari, Macrae, Erin R., Lustberg, Maryam B., Reinbolt, Raquel E., Mrozek, Ewa, Byrd, John C., Caligiuri, Michael A., Mace, Thomas A., Carson, William E.
Format: Article
Language:English
Subjects:
Adult
African Americans
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Blood levels
Breast cancer
Breast Neoplasms - blood
Breast Neoplasms - drug therapy
Breast Neoplasms - ethnology
Cancer Research
Cell Count
Chemotherapy
Chemotherapy, Adjuvant
Cyclophosphamide
Cyclophosphamide - administration & dosage
Cytokines - blood
Doxorubicin
Doxorubicin - administration & dosage
ErbB-2 protein
European Continental Ancestry Group
Female
Flow cytometry
Granulocytes - drug effects
Granulocytes - pathology
Humans
Immunology
Medicine
Medicine & Public Health
Middle Aged
Minority & ethnic groups
Monocytes
Monocytes - drug effects
Monocytes - pathology
Myeloid-Derived Suppressor Cells - drug effects
Myeloid-Derived Suppressor Cells - pathology
Neoadjuvant Therapy
Oncology
Original Article
Paclitaxel
Paclitaxel - administration & dosage
Peripheral blood
Pilot Projects
Suppressor cells
Treatment Outcome
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Summary:This study sought to evaluate whether myeloid-derived suppressor cells (MDSC) could be affected by chemotherapy and correlate with pathologic complete response (pCR) in breast cancer patients receiving neo-adjuvant chemotherapy. Peripheral blood levels of granulocytic (G-MDSC) and monocytic (M-MDSC) MDSC were measured by flow cytometry prior to cycle 1 and 2 of doxorubicin and cyclophosphamide and 1st and last administration of paclitaxel or paclitaxel/anti-HER2 therapy. Of 24 patients, 11, 6 and 7 patients were triple negative, HER2+ and hormone receptor+, respectively. 45.8% had pCR. Mean M-MDSC% were
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-017-2038-3