Transforming growth factor-β signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population

• Published in: Scientific reports 2017-10, Vol.7 (1), p.13589-8, Article 13589
• Main Authors: Lin, Eugene, Kuo, Po-Hsiu, Liu, Yu-Li, Yang, Albert C., Tsai, Shih-Jen
• Format: Article
• Language: English
• Subjects: 45; 45/47; 631/208/721; 692/4017; 692/699/2743/2037; Adult; Asian People - genetics; Blood pressure; Cholesterol; Female; Genes; Genetic Predisposition to Disease; Growth factors; Humanities and Social Sciences; Humans; Low density lipoprotein; Male; Metabolic syndrome; Metabolic Syndrome - genetics; Metabolic Syndrome - metabolism; Middle Aged; multidisciplinary; Polymorphism, Single Nucleotide; Receptor, Transforming Growth Factor-beta Type II - genetics; Receptor, Transforming Growth Factor-beta Type II - metabolism; Science; Science (multidisciplinary); Signal transduction; Signal Transduction - genetics; Single-nucleotide polymorphism; Smad protein; Smad2 protein; Smad2 Protein - genetics; Smad2 Protein - metabolism; Smad3 protein; Smad4 protein; Taiwan; Transforming Growth Factor beta - metabolism; Transforming growth factor-b; Transforming growth factor-b1
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-14025-4

The transforming growth factor-β (TGF-β) signaling pathway and its relevant genes have been correlated with an increased risk of developing various hallmarks of metabolic syndrome (MetS). In this study, we assessed whether the TGF-β signaling pathway-associated genes of SMAD family member 2 ( SMAD2 ), SMAD3 , SMAD4 , transforming growth factor beta 1 ( TGFB1 ), TGFB2 , TGFB3 , transforming growth factor beta receptor 1 ( TGFBR1 ), and TGFBR2 are associated with MetS and its individual components independently, through complex interactions, or both in a Taiwanese population. A total of 3,000 Taiwanese subjects from the Taiwan Biobank were assessed. Metabolic traits such as waist circumference, triglyceride, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, and fasting glucose were measured. Our results showed a significant association of MetS with the two single nucleotide polymorphisms (SNPs) of SMAD2 rs11082639 and TGFBR2 rs3773651. The association of MetS with these SNPs remained significant after performing Bonferroni correction. Moreover, we identified the effect of SMAD2 rs11082639 on high waist circumference. We also found that an interaction between the SMAD2 rs11082639 and TGFBR2 rs3773651 SNPs influenced MetS. Our findings indicated that the TGF-β signaling pathway-associated genes of SMAD2 and TGFBR2 may contribute to the risk of MetS independently and through gene–gene interactions.