Neuroendocrine Differentiation of Prostate Cancer Metastases Evidenced “in Vivo” by 68Ga-DOTANOC PET/CT: Two Cases

Prostate cancer is the second most commonly diagnosed neoplasm in men. This neoplasm has usually excellent prognosis, mostly consequent to the early diagnosis and the effective hormonal therapy. However, significant percentages of patients treated with total androgen blockade therapy, escape to trea...

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Published in:World journal of oncology 2014-04, Vol.5 (2), p.72-76
Main Authors: Savelli, Giordano, Muni, Alfredo, Barbieri, Roberto, Valmadre, Giuseppe, Biasiotto, Giorgio, Minari, Chiara, Ghimenton, Claudio, Pagani, Renato, Pecini, Elisa, Falcone, Matteo
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container_issue 2
container_start_page 72
container_title World journal of oncology
container_volume 5
creator Savelli, Giordano
Muni, Alfredo
Barbieri, Roberto
Valmadre, Giuseppe
Biasiotto, Giorgio
Minari, Chiara
Ghimenton, Claudio
Pagani, Renato
Pecini, Elisa
Falcone, Matteo
description Prostate cancer is the second most commonly diagnosed neoplasm in men. This neoplasm has usually excellent prognosis, mostly consequent to the early diagnosis and the effective hormonal therapy. However, significant percentages of patients treated with total androgen blockade therapy, escape to treatment and evolve toward a more aggressive type of cancer. This clinical entity, named castration-resistant prostate cancer, has few and less effective therapeutic opportunities. Therefore, any additional information concerning possible biological targets to therapy is welcome. Here we describe two cases in which 68 Ga-DOTANOC PET/CT evidenced the somatostatin receptor overexpression by prostate metastases. The presence of these receptors may support with a more strong evidence the possibility to administer somatostatin analogs as an adjuvant therapy.
doi_str_mv 10.14740/wjon739w
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title Neuroendocrine Differentiation of Prostate Cancer Metastases Evidenced “in Vivo” by 68Ga-DOTANOC PET/CT: Two Cases
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