Co-existence of Diffuse Serous Cystadenoma and Pancreatic Neuroendocrine Tumor

Diffuse serous cystic neoplasm (SCN) associated with pancreatic neuroendocrine tumor (PNET) is a rare finding reported previously in only three patients to the best of our knowledge. We herein present one such interesting report of a diffuse serous cystic adenoma (SCA) and co-existent PNET in a 25-y...

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Bibliographic Details
Published in:Indian journal of surgery 2017-10, Vol.79 (5), p.455-457
Main Authors: Tewari, Mallika, Patne, Shashikant, Katiyar, Richa, Biswas, Dipanjan, Shukla, HS
Format: Article
Language:English
Subjects:
Cardiac Surgery
Case Report
Cysts
Medicine
Medicine & Public Health
Neurosurgery
Pancreatic cancer
Pediatric Surgery
Plastic Surgery
Stem cells
Surgery
Thoracic Surgery
Tumors
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Summary:Diffuse serous cystic neoplasm (SCN) associated with pancreatic neuroendocrine tumor (PNET) is a rare finding reported previously in only three patients to the best of our knowledge. We herein present one such interesting report of a diffuse serous cystic adenoma (SCA) and co-existent PNET in a 25-year old lady who presented with abdominal pain for past 6 months. A triple-phase pancreatic protocol computed tomography (CT) scan revealed multiple cysts involving the entire pancreas. The cysts were thin walled, ranging from 2 to 8 cm in width, with no calcification or central scar that was confirmed at laparotomy. A frozen section revealed a neuroendocrine tumor and she underwent total pancreatectomy. Diffuse SCA with co-existent PNET infiltrating nerve bundles of the pancreatic parenchyma was made upon histopathology further verified by chromogranin-A immunostaining. The patient is insulin dependent and doing well at 2 years of follow-up. The origin of endocrine tumors from multipotent ductular stem cells has been suggested.
ISSN:0972-2068
0973-9793
DOI:10.1007/s12262-017-1593-3