Passive and Active Triaxial Wall Mechanics in a Two-Layer Model of Porcine Coronary Artery

• Published in: Scientific reports 2017-10, Vol.7 (1), p.13911-12, Article 13911
• Main Authors: Lu, Yuan, Wu, Hao, Li, Jiahang, Gong, Yanjun, Ma, Jiahui, Kassab, Ghassan S., Huo, Yong, Tan, Wenchang, Huo, Yunlong
• Format: Article
• Language: English
• Subjects: 13/107; 639/166/985; 639/301/54/994; Cardiovascular disease; Computer applications; Contraction; Coronary artery; Coronary vessels; Experiments; Genetic algorithms; Humanities and Social Sciences; Mechanical properties; Mechanics; multidisciplinary; Muscle contraction; Science; Science (multidisciplinary); Smooth muscle
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-14276-1

Triaxial active and passive mechanical properties of coronary arteries are needed for understanding arterial mechanics in health and disease. The aim of the study was to quantify both active and passive strain energy functions in circumferential, axial and radial directions based on the experimental measurement. Moreover, a two-layer computational model was used to determine the transmural distribution of stresses and strains across the vessel wall. The first Piola-Kirchhoff stresses in the three normal directions had the approximate relationship as: T θ θ ≅ 2 T z z ≅ 5 | T r r | . The two-layer model showed that circumferential Cauchy stresses increased significantly from the intima layer to the interface between media and adventitia layers (from ~80 to 160 kPa), dropped abruptly at the interface (from ~160 to