Age at Menarche and Late Adolescent Adiposity Associated with Mammographic Density on Processed Digital Mammograms in 24,840 Women

High mammographic density is strongly associated with increased breast cancer risk. Some, but not all, risk factors for breast cancer are also associated with higher mammographic density. The study cohort ( = 24,840) was drawn from the Research Program in Genes, Environment and Health of Kaiser Perm...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2017-09, Vol.26 (9), p.1450-1458
Main Authors: Alexeeff, Stacey E, Odo, Nnaemeka U, Lipson, Jafi A, Achacoso, Ninah, Rothstein, Joseph H, Yaffe, Martin J, Liang, Rhea Y, Acton, Luana, McGuire, Valerie, Whittemore, Alice S, Rubin, Daniel L, Sieh, Weiva, Habel, Laurel A
Format: Article
Language:English
Subjects:
Adipose tissue
Adiposity - physiology
Age
Age factors
Body mass
Body mass index
Breast - pathology
Breast cancer
Cohort Studies
Density
Female
Females
Health risks
Humans
Long-term effects
Mammography
Mammography - methods
Menarche
Menarche - physiology
Middle Aged
Risk factors
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Summary:High mammographic density is strongly associated with increased breast cancer risk. Some, but not all, risk factors for breast cancer are also associated with higher mammographic density. The study cohort ( = 24,840) was drawn from the Research Program in Genes, Environment and Health of Kaiser Permanente Northern California and included non-Hispanic white females ages 40 to 74 years with a full-field digital mammogram (FFDM). Percent density (PD) and dense area (DA) were measured by a radiological technologist using Cumulus. The association of age at menarche and late adolescent body mass index (BMI) with PD and DA were modeled using linear regression adjusted for confounders. Age at menarche and late adolescent BMI were negatively correlated. Age at menarche was positively associated with PD ( value for trend
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-17-0264