Prevalence of cytotoxin-associated genes of Helicobacter pylori among Iranian GERD patients

• Published in: Gastroenterology and hepatology from bed to bench 2017, Vol.10 (3), p.178-183
• Main Authors: Shavalipour, Aref, Malekpour, Habib, Dabiri, Hossein, Kazemian, Hossein, Zojaji, Homayon, Bahroudi, Mahboube
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 2008-2258; 2008-4234
• DOI: 10.22037/ghfbb.v0i0.1062

Since the impact of and its virulence is not clear in GERD, this study aimed to evaluate the prevalence of and gens of among Iranian GERD patients. Gastroesophageal reflux disease (GERD) is defined as a condition of reflux the stomach juice by low pH causes tissue damage. may or may not influence the GERD; however, it is unclear. This study was a case-control study performed on patients with GERD who underwent upper gastrointestinal endoscopy at Taleghani Hospital of Tehran, Iran. Prevalence of H. pylori and presence of the cag and genes in GERD and control group was investigated. was detected in 54% and 62% of GERD and control groups respectively. Prevalence of gene among GERD patients was 44.4% whereas among the control group it was 87%. Prevalence of the among GERD patients and control group was 44.4% and 64% respectively. Coexistence of and in GERD patients was 25.7% and in the control patients it was 54.8%. We did not find correlation between existence in GERD patients in comparison to the control group. Similar to other Asian studies, the presence of the c in control group was more than GERD patients significantly. The co-existence of and was also more in control group significantly.