Association between Endothelin-1 Levels and Kidney Disease among Blacks

Endothelin-1, a marker of endothelial dysfunction, is a potent vasoconstrictor released by endothelial cells and an important regulator of renal physiology. It is not known whether elevated serum levels of endothelin-1 indicate future risk of kidney disease in the general population. In participants...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 2017-11, Vol.28 (11), p.3337-3344
Main Authors: Rebholz, Casey M, Harman, Jane L, Grams, Morgan E, Correa, Adolfo, Shimbo, Daichi, Coresh, Josef, Young, Bessie A
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group
Aged
Aged, 80 and over
Clinical Epidemiology
Disease Progression
Endothelin-1 - blood
Female
Glomerular Filtration Rate
Humans
Male
Middle Aged
Prospective Studies
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - physiopathology
Young Adult
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Summary:Endothelin-1, a marker of endothelial dysfunction, is a potent vasoconstrictor released by endothelial cells and an important regulator of renal physiology. It is not known whether elevated serum levels of endothelin-1 indicate future risk of kidney disease in the general population. In participants in the Jackson Heart Study, a community-based observational study of cardiovascular risk in black adults, we measured serum endothelin-1 level at baseline (2000-2004; =3538). We defined incident CKD as eGFR
ISSN:1046-6673
1533-3450
DOI:10.1681/asn.2016111236