The expression profile and clinical significance of circRNA0003906 in colorectal cancer

Colorectal cancer (CRC) remains a major health problem worldwide and the detailed mechanisms of CRC still need further understanding. Circular RNAs (circRNAs), a special class of endogenous RNAs, have emerged recently as a new potential player in governing fundamental biological process and cancer p...

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Bibliographic Details
Published in:OncoTargets and therapy 2017-01, Vol.10, p.5187-5193
Main Authors: Zhuo, Fan, Lin, Huashan, Chen, Zhixin, Huang, Zhijun, Hu, Jiaping
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Cancer therapies
Care and treatment
Cell growth
Chemotherapy
Clinical significance
Colorectal cancer
Development and progression
Diagnosis
Gastric cancer
Gene expression
Hospitals
Medical prognosis
Original Research
Patients
Polymerase chain reaction
Prognosis
Radiation therapy
Surgery
Tumors
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Summary:Colorectal cancer (CRC) remains a major health problem worldwide and the detailed mechanisms of CRC still need further understanding. Circular RNAs (circRNAs), a special class of endogenous RNAs, have emerged recently as a new potential player in governing fundamental biological process and cancer progression. In this study, we chose circRNA0003906 as a targeted circRNA to evaluate its expression pattern and clinical value in CRC patients. circRNA0003906 expression level in 6 CRC cell lines and 122 paired CRC tissues was measured by quantitative real-time polymerase chain reaction. Then, the potential correlation between circRNA0003906 expression level and clinicopathological factors of CRC patients was analyzed. Additionally, a receiver operating characteristic curve was built to evaluate the diagnostic value of circRNA0003906. Our results showed that circRNA0003906 expression level was dramatically downregulated in both CRC tissues and cell lines. Moreover, the downregulation of circRNA0003906 level significantly correlated with lymphatic metastasis and poor differentiation. In addition, the area under the receiver operating characteristic curve of circRNA0003906 for CRC was 0.818 (
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S147378