Prognostic role of FDG PET/CT in patients with differentiated thyroid cancer treated with 131-iodine empiric therapy

To assess the long-term prognostic value of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg). Forty-nine patients with...

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Published in:Medicine (Baltimore) 2017-10, Vol.96 (42), p.e8344-e8344
Main Authors: Salvatore, Barbara, Klain, Michele, Nicolai, Emanuele, D’Amico, Domenico, De Matteis, Gianluca, Raddi, Marco, Fonti, Rosa, Pellegrino, Teresa, Storto, Giovanni, Cuocolo, Alberto, Pace, Leonardo
Format: Article
Language:English
Subjects:
Adult
Aged
Diagnostic Accuracy Study
Disease-Free Survival
Female
Fluorodeoxyglucose F18
Humans
Iodine Radioisotopes - therapeutic use
Male
Middle Aged
Positron Emission Tomography Computed Tomography
Prognosis
Radiopharmaceuticals - therapeutic use
Retrospective Studies
Thyroglobulin - biosynthesis
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - drug therapy
Thyroid Neoplasms - mortality
Thyroid Neoplasms - pathology
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Summary:To assess the long-term prognostic value of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg). Forty-nine patients with histological diagnosis of DTC (31 with papillary and 18 with follicular carcinoma) follow-up for a mean period of 7.9 ± 5 years after empiric RAI therapy were retrospectively analyzed. FDG-PET/CT was negative in 15 (30.6%) patients and positive in 34 (69.4%), whereas postradioiodine therapy whole body scan (t-WBS) was negative in 16 (32.7%) and positive in 33 (67.3%) patients. FDG-PET/CT and t-WBS were in agreement in 32 patients (7 both negative and 25 both positive); on the contrary, in 17 patients there was disagreement between FDG-PET/CT and t-WBS (P =ns). At short-term follow-up, Tg normalized in 19 (38.8%) patients and was unchanged or increased in 30 (61.2%). Of the 15 patients with negative FDG-PET/CT, 11 (73.3%) showed Tg normalization, whereas of the 34 patients with positive FDG-PET/CT, only 8 (23.5%) had Tg normalization (χ =8.9, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000008344