Modulating Neuroinflammation to Treat Neuropsychiatric Disorders

Neuroinflammation is recognised as one of the potential mechanisms mediating the onset of a broad range of psychiatric disorders and may contribute to nonresponsiveness to current therapies. Both preclinical and clinical studies have indicated that aberrant inflammatory responses can result in alter...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-21
Main Authors: Syed, Yasir A., Hall, Jeremy, Chapman, Gareth, Radtke, Franziska A.
Format: Article
Language:English
Subjects:
Aberration
Anxiety
Bipolar disorder
Care and treatment
Cognitive ability
Cognitive Dysfunction - genetics
Cognitive Dysfunction - metabolism
Cognitive Dysfunction - physiopathology
Cognitive Dysfunction - therapy
Disorders
Genetic Variation
Humans
Inflammation
Inflammation - genetics
Inflammation - metabolism
Inflammation - physiopathology
Inflammation - therapy
Mental depression
Mental disorders
Mental illness
Pathogenesis
Review
Therapeutic applications
Tumor necrosis factor-TNF
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Summary:Neuroinflammation is recognised as one of the potential mechanisms mediating the onset of a broad range of psychiatric disorders and may contribute to nonresponsiveness to current therapies. Both preclinical and clinical studies have indicated that aberrant inflammatory responses can result in altered behavioral responses and cognitive deficits. In this review, we discuss the role of inflammation in the pathogenesis of neuropsychiatric disorders and ask the question if certain genetic copy-number variants (CNVs) associated with psychiatric disorders might play a role in modulating inflammation. Furthermore, we detail some of the potential treatment strategies for psychiatric disorders that may operate by altering inflammatory responses.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/5071786