Endocrine Disruptors Leading to Obesity and Related Diseases

The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong particip...

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Bibliographic Details
Published in:International journal of environmental research and public health 2017-10, Vol.14 (10), p.1282
Main Authors: Petrakis, Demetrios, Vassilopoulou, Loukia, Mamoulakis, Charalampos, Psycharakis, Christos, Anifantaki, Aliki, Sifakis, Stavros, Docea, Anca Oana, Tsiaoussis, John, Makrigiannakis, Antonios, Tsatsakis, Aristides M
Format: Article
Language:English
Subjects:
Androgens
Carcinogenesis
Carcinogenicity
Carcinogens
Cardiovascular diseases
Cardiovascular Diseases - etiology
Diabetes mellitus
Endocrine disruptors
Endocrine Disruptors - toxicity
Energy management
Environmental conditions
Epidemics
Exposure
Fatty Liver - etiology
Hormones
Humans
Infertility
Infertility - etiology
Inflammation
Metabolic syndrome
Metabolic Syndrome - etiology
Morbidity
Neoplasms - etiology
Obesity
Obesity - etiology
Pesticides
Review
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Summary:The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong participants in the obesity epidemic scenery by interfering with cellular morphological and biochemical processes; by inducing inflammatory responses; and by presenting transcriptional and oncogenic activity. Obesity and lipotoxicity enhancement occur through reprogramming and/or remodeling of germline epigenome by exposure to EDs. Specific population groups are vulnerable to ED exposure due to current dietary and environmental conditions. Obesity, morbidity and carcinogenicity induced by ED exposure are an evolving reality. Therefore, a new collective strategic approach is deemed essential, for the reappraisal of current global conditions pertaining to energy management.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph14101282