Combination therapy with extracorporeal shock wave and melatonin markedly attenuated neuropathic pain in rat

This study tested the hypothesis that combination therapy using extracorporeal shock wave (ECSW)-melatonin (Mel) was superior to either alone at ameliorating neuropathic pain (NP). NP was induced by chronic constriction injury (CCI) to the left sciatic nerve in rats. Animals were categorized into sh...

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Published in:American journal of translational research 2017-01, Vol.9 (10), p.4593-4606
Main Authors: Chen, Kuan-Hung, Yang, Chien-Hui, Wallace, Christopher Glenn, Lin, Chung-Ren, Liu, Chia-Kai, Yin, Tsung-Cheng, Huang, Tien-Hung, Chen, Yi-Ling, Sun, Cheuk-Kwan, Yip, Hon-Kan
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Language:English
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Summary:This study tested the hypothesis that combination therapy using extracorporeal shock wave (ECSW)-melatonin (Mel) was superior to either alone at ameliorating neuropathic pain (NP). NP was induced by chronic constriction injury (CCI) to the left sciatic nerve in rats. Animals were categorized into sham control (group 1), CCI only (group 2), CCI-ECSW (group 3), CCI-Mel (group 4) and CCI-ECSW-Mel (group 5). By days 2 and 8 after CCI, the mechanical paw withdrawal threshold (MPWT)/thermal paw withdrawal latency (TPWL) were highest in group 2, lowest in group 1, significantly lower in group 5 than in groups 3 and 4 (all p
ISSN:1943-8141
1943-8141