Sports and HDL-Quality Reflected By Serum Amyloid A and Surfactant Protein B

• Published in: International journal of medical sciences 2017-01, Vol.14 (11), p.1040-1048
• Main Authors: Sponder, Michael, Kopecky, Chantal, Campean, Ioana-Alexandra, Emich, Michael, Fritzer-Szekeres, Monika, Litschauer, Brigitte, Graf, Senta, Säemann, Marcus D, Strametz-Juranek, Jeanette
• Format: Article
• Language: English
• Subjects: Research Paper
• ISSN: 1449-1907; 1449-1907
• DOI: 10.7150/ijms.20388

: The aim of this prospective study was to investigate the influence of long-term physical activity on HDL quality, reflected by serum amyloid A (SAA) and surfactant protein B (SPB). : 109 healthy subjects were recruited, 98 completed the study. Participants perform within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period. SAA and SPB were measured at baseline and after 4 and 8 months by ELISA. In contrary to HDL-quantity, there was no sports-induced change in SAA or SPB observable. However, significant predictors for SPB-levels were smoking status, BMI and weekly alcohol consumption and for SAA weekly alcohol consumption together with sex and hsCRP-levels. : Long-term physical activity increases HDL-quantity but has no impact on HDL-quality reflected by SAA and SPB. Smoking is associated with higher SPB-levels and the weekly alcohol intake is associated with both higher SAA and SPB-levels suggesting a damaging effect of smoking and drinking alcohol on the HDL-quality. We assume that HDL-quality is at least as important as HDL-quantity when investigating the role of HDL in (cardiovascular) disease and should receive attention in further studies dealing with HDL.