Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight

Spaceflight entails exposure to numerous environmental challenges with the potential to contribute to both musculoskeletal and vascular dysfunction. The purpose of this review is to describe current understanding of microgravity and radiation impacts on the mammalian skeleton and associated vasculat...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-10, Vol.18 (10), p.2153
Main Authors: Tahimic, Candice G T, Globus, Ruth K
Format: Article
Language:English
Subjects:
Aging
Antioxidants
Apoptosis
Astronauts
Bone marrow
Cell cycle
Gene expression
Lipids
Metabolism
Oxidative stress
Radiation
Review
Skeleton
Space flight
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Summary:Spaceflight entails exposure to numerous environmental challenges with the potential to contribute to both musculoskeletal and vascular dysfunction. The purpose of this review is to describe current understanding of microgravity and radiation impacts on the mammalian skeleton and associated vasculature at the level of the whole organism. Recent experiments from spaceflight and ground-based models have provided fresh insights into how these environmental stresses influence mechanisms that are related to redox signaling, oxidative stress, and tissue dysfunction. Emerging mechanistic knowledge on cellular defenses to radiation and other environmental stressors, including microgravity, are useful for both screening and developing interventions against spaceflight-induced deficits in bone and vascular function.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18102153