Production of Poly(ε-Caprolactone)/Hydroxyapatite Composite Scaffolds with a Tailored Macro/Micro-Porous Structure, High Mechanical Properties, and Excellent Bioactivity

We produced poro-us poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) composite scaffolds for bone regeneration, which can have a tailored macro/micro-porous structure with high mechanical properties and excellent in vitro bioactivity using non-solvent-induced phase separation (NIPS)-based 3D plotting....

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Bibliographic Details
Published in:Materials 2017-09, Vol.10 (10), p.1123
Main Authors: Kim, Jong-Woo, Shin, Kwan-Ha, Koh, Young-Hag, Hah, Min Jin, Moon, Jiyoung, Kim, Hyoun-Ee
Format: Article
Language:English
Subjects:
Addition polymerization
Apatite
Biological activity
Biomedical materials
Compressive strength
Filaments
Hydroxyapatite
Mechanical properties
Particulate composites
Phase separation
Plotting
Polycaprolactone
Pore size
Porosity
Regeneration (physiology)
Scaffolds
Solvents
Struts
Surgical implants
Tissue engineering
Ultimate tensile strength
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Summary:We produced poro-us poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) composite scaffolds for bone regeneration, which can have a tailored macro/micro-porous structure with high mechanical properties and excellent in vitro bioactivity using non-solvent-induced phase separation (NIPS)-based 3D plotting. This innovative 3D plotting technique can create highly microporous PCL/HA composite filaments by inducing unique phase separation in PCL/HA solutions through the non-solvent-solvent exchange phenomenon. The PCL/HA composite scaffolds produced with various HA contents (0 wt %, 10 wt %, 15 wt %, and 20 wt %) showed that PCL/HA composite struts with highly microporous structures were well constructed in a controlled periodic pattern. Similar levels of overall porosity (~78 vol %) and pore size (~248 µm) were observed for all the PCL/HA composite scaffolds, which would be highly beneficial to bone tissue regeneration. Mechanical properties, such as ultimate tensile strength and compressive yield strength, increased with an increase in HA content. In addition, incorporating bioactive HA particles into the PCL polymer led to remarkable enhancements in in vitro apatite-forming ability.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma10101123