Clinical Significance of Routine Blood Test-Associated Inflammatory Index in Breast Cancer Patients

BACKGROUND It is now widely acknowledged that chronic inflammation is closely associated with the process of cancer development. As a simple noninvasive blood-based test, hematological parameters in the routine blood test have been considered as inflammation markers. We aimed to evaluate platelet co...

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Bibliographic Details
Published in:Medical science monitor 2017-10, Vol.23, p.5090-5095
Main Authors: Sun, Hong, Yin, Chang-Qing, Liu, Qing, Wang, Fubing, Yuan, Chun-Hui
Format: Article
Language:English
Subjects:
Breast Neoplasms - blood
Breast Neoplasms - pathology
Case-Control Studies
Clinical Research
Demography
Diagnostic Tests, Routine
Female
Hematologic Tests
Humans
Inflammation - blood
Inflammation - pathology
Logistic Models
Lymphocyte Count
Lymphocytes - pathology
Mean Platelet Volume
Middle Aged
Multivariate Analysis
Neutrophils - pathology
Platelet Count
Risk Factors
ROC Curve
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Summary:BACKGROUND It is now widely acknowledged that chronic inflammation is closely associated with the process of cancer development. As a simple noninvasive blood-based test, hematological parameters in the routine blood test have been considered as inflammation markers. We aimed to evaluate platelet count (PC), red blood cell distribution width (RDW), white blood cell count (WBC), mean platelet volume (MPV), number of neutrophils/lymphocytes ratio (NLR), and platelet count/lymphocytes ratio (PLR) as surrogate inflammatory markers in breast cancer (BC) patients, and we compared these to those in healthy individuals. MATERIAL AND METHODS A retrospective study was conducted in Zhongnan Hospital of Wuhan University from July 2014 to April 2015, including 110 cases of pathologically diagnosed BC patients and 78 cases of healthy females. Retrospective analysis of selected hematological parameters was performed between the 2 groups, as well as assessment of the correlation between these indexes and clinicopathological characteristics of the 110 breast cancer patients. RESULTS The mean values of RDW, MPV, NLR, and PLR were significantly higher in BC patients compared to the control group. The level of MPV exhibited positive correlations with lymph node metastasis and the Ki67 proliferation index in preoperative BC patients (P
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.906709