Intravascular Optical Coherence Tomography for Characterization of Atherosclerosis with a 1.7 Micron Swept-Source Laser

The main cause of acute coronary events, such as thrombosis, is the rupture of atherosclerotic plaques. Typical intravascular optical coherence tomography (IVOCT) imaging systems that utilize a 1.3 μm swept source laser are often used for identifying fibrous cap thickness of plaques, yet cannot prov...

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Bibliographic Details
Published in:Scientific reports 2017-11, Vol.7 (1), p.14525-6, Article 14525
Main Authors: Li, Yan, Jing, Joseph, Heidari, Emon, Zhu, Jiang, Qu, Yueqiao, Chen, Zhongping
Format: Article
Language:English
Subjects:
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Arteriosclerosis
Atherosclerosis
Coronary artery
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - pathology
Coronary Vessels - diagnostic imaging
Coronary Vessels - pathology
Endoscopes
Equipment Design
Histology
Humanities and Social Sciences
Humans
Lasers
Light sources
Medical imaging
multidisciplinary
Phantoms, Imaging
Plaque, Atherosclerotic - diagnostic imaging
Plaque, Atherosclerotic - pathology
Plaques
Science
Science (multidisciplinary)
Sensitivity and Specificity
Thromboembolism
Thrombosis
Tomography
Tomography, Optical Coherence - instrumentation
Tomography, Optical Coherence - methods
Wavelength
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Summary:The main cause of acute coronary events, such as thrombosis, is the rupture of atherosclerotic plaques. Typical intravascular optical coherence tomography (IVOCT) imaging systems that utilize a 1.3 μm swept source laser are often used for identifying fibrous cap thickness of plaques, yet cannot provide adequate depth penetration to resolve the size of the lipid pool. Here, we present a novel  IVOCT system with a 1.7 μm center wavelength swept light source that can readily penetrate deeper into the tissue because of the longer wavelength and allows for better identification of plaques due to the lipid absorption spectrum at 1.7 μm. Using this system, we have imaged a human coronary artery to evaluate the performance of the novel OCT system and verified the results by hematoxylin and eosin (H&E) histology. The significantly improved imaging depth and better identification sensitivity suggest that the 1.7 μm OCT system holds great potential  that can be further translated for in-vivo applications of atherosclerosis characterization.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-15326-4