Isoniazid-induced Pure Red Cell Aplasia in a Patient with Sarcoidosis: A Patient Summary and Review of the Literature

A 41-year-old woman treated with isoniazid (INH) for latent tuberculosis infection and an oral corticosteroid for sarcoidosis developed severe anemia two months after initiating INH. A bone marrow examination showed erythroblastopenia, and a diagnosis of INH-induced pure red cell aplasia (PRCA) was...

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Bibliographic Details
Published in:Internal Medicine 2017/10/15, Vol.56(20), pp.2753-2757
Main Authors: Saito, Yasuyuki, Sawada, Yuri, Koga, Yasuhiko, Sunaga, Noriaki, Tsukagoshi, Yusuke, Hachisu, Yoshimasa, Osaki, Takashi, Sakurai, Reiko, Kaira, Kyoichi, Ono, Akihiro, Sato, Ken, Koiso, Hiromi, Oyama, Tetsunari, Hisada, Takeshi, Yamada, Masanobu
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Antitubercular Agents - administration & dosage
Antitubercular Agents - therapeutic use
Aplasia
Autoimmune diseases
autoimmune disorders
biological drug
Bone marrow
Case Report
Corticosteroids
Female
Hemoglobin
Humans
Internal medicine
Isoniazid
Isoniazid - adverse effects
Isoniazid - therapeutic use
Latent Tuberculosis - complications
Latent Tuberculosis - drug therapy
latent tuberculosis infection
Literature reviews
pure red cell aplasia
Red-Cell Aplasia, Pure - chemically induced
Sarcoidosis
Sarcoidosis - complications
Sarcoidosis - drug therapy
Tuberculosis
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Description
Summary:A 41-year-old woman treated with isoniazid (INH) for latent tuberculosis infection and an oral corticosteroid for sarcoidosis developed severe anemia two months after initiating INH. A bone marrow examination showed erythroblastopenia, and a diagnosis of INH-induced pure red cell aplasia (PRCA) was made. Her reticulocyte count and hemoglobin levels improved two weeks after discontinuation of INH. A literature review of INH-induced PRCA shows that it occurs very rarely in the context of autoimmune disorders. This report describes a case of INH-induced PRCA occurring in a patient with sarcoidosis.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.8379-16