Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy

Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly expressed in diabetic nephropathy (DN) may be involv...

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Published in:Scientific reports 2017-11, Vol.7 (1), p.15160-11, Article 15160
Main Authors: Krochmal, Magdalena, Kontostathi, Georgia, Magalhães, Pedro, Makridakis, Manousos, Klein, Julie, Husi, Holger, Leierer, Johannes, Mayer, Gert, Bascands, Jean-Loup, Denis, Colette, Zoidakis, Jerome, Zürbig, Petra, Delles, Christian, Schanstra, Joost P., Mischak, Harald, Vlahou, Antonia
Format: Article
Language:English
Subjects:
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Cathepsin D
Deregulation
Diabetes
Diabetes mellitus
Diabetic nephropathy
Gelatinase A
Gelatinase B
Humanities and Social Sciences
Investigations
Life Sciences
multidisciplinary
Nephropathy
Peptides
Proprotein convertases
Proteolysis
Rodents
Science
Science (multidisciplinary)
Urine
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Summary:Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly expressed in diabetic nephropathy (DN) may be involved in the generation of DN-associated peptides in urine. We compared urinary peptide profiles of DN patients (macroalbuminuric, n = 121) to diabetic patients with no evidence of DN (normoalbuminuric, n = 118). 302 sequenced, differentially expressed peptides (adjusted p-value 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-15359-9