Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR

Abstract Mitochondria form a cellular network of organelles, or cellular compartments, that efficiently couple nutrients to energy production in the form of ATP. As cancer cells rely heavily on glycolysis, historically mitochondria and the cellular pathways in place to maintain mitochondrial activit...

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Bibliographic Details
Published in:Seminars in cancer biology 2017-12, Vol.47, p.43-49
Main Authors: Deng, Pan, Haynes, Cole M
Format: Article
Language:English
Subjects:
Activating Transcription Factors - genetics
Activating Transcription Factors - metabolism
Animals
ATF5
Cancer
Gene Expression Regulation, Neoplastic
Hematology, Oncology and Palliative Medicine
Humans
Mitochondria
Mitochondria - metabolism
Neoplasms - etiology
Neoplasms - metabolism
Signal Transduction
Stress, Physiological
Unfolded Protein Response
UPRmt
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Summary:Abstract Mitochondria form a cellular network of organelles, or cellular compartments, that efficiently couple nutrients to energy production in the form of ATP. As cancer cells rely heavily on glycolysis, historically mitochondria and the cellular pathways in place to maintain mitochondrial activities were thought to be more relevant to diseases observed in non-dividing cells such as muscles and neurons. However, more recently it has become clear that cancers rely heavily on mitochondrial activities including lipid, nucleotide and amino acid synthesis, suppression of mitochondria-mediated apoptosis as well as oxidative phosphorylation (OXPHOS) for growth and survival. Considering the variety of conditions and stresses that cancer cell mitochondria may incur such as hypoxia, reactive oxygen species and mitochondrial genome mutagenesis, we examine potential roles for a mitochondrial-protective transcriptional response known as the mitochondrial unfolded protein response (UPRmt ) in cancer cell biology.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2017.05.002