Role of MicroRNA Regulation in Obesity-Associated Breast Cancer: Nutritional Perspectives

Breast cancer is the most common malignancy diagnosed in women, and the incidence of breast cancer is increasing every year. Obesity has been identified as one of the major risk factors for breast cancer progression. The mechanisms by which obesity contributes to breast cancer development is not yet...

Full description

Saved in:
Bibliographic Details
Published in:Advances in nutrition (Bethesda, Md.) Md.), 2017-11, Vol.8 (6), p.868-888
Main Authors: Kasiappan, Ravi, Rajarajan, Dheeran
Format: Article
Language:English
Subjects:
adipocyte
breast cancer
Breast Neoplasms - etiology
Breast Neoplasms - genetics
Diet - adverse effects
dietary components
Female
Humans
microRNA
MicroRNAs - metabolism
obesity
Obesity - complications
Obesity - genetics
Reviews
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Breast cancer is the most common malignancy diagnosed in women, and the incidence of breast cancer is increasing every year. Obesity has been identified as one of the major risk factors for breast cancer progression. The mechanisms by which obesity contributes to breast cancer development is not yet understood; however, there are a few mechanisms counted as potential producers of breast cancer in obesity, including insulin resistance, chronic inflammation and inflammatory cytokines, adipokines, and sex hormones. Recent emerging evidence suggests that alterations in microRNA (miRNA) expressions are found in several diseases, including breast cancer and obesity; however, miRNA roles in obesity-linked breast cancer are beginning to unravel. miRNAs are thought to be potential noninvasive biomarkers for diagnosis and prognosis of cancer patients with comorbid conditions of obesity as well as therapeutic targets. Recent studies have evidenced that nutrients and other dietary factors protect against cancer and obesity through modulation of miRNA expressions. Herein, we summarize a comprehensive overview of up-to-date information related to miRNAs and their molecular targets involved in obesity-associated breast cancer. We also address the mechanisms by which dietary factors modulate miRNA expression and its protective roles in obesity-associated breast cancer. It is hoped that this review would provide new therapeutic strategies for the treatment of obesity-associated breast cancer to reduce the burden of breast cancer.
ISSN:2161-8313
2156-5376
DOI:10.3945/an.117.015800