Zinc-finger proteins in health and disease

Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other proteins. Thus, ZNFs are involved in the regulation of sev...

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Bibliographic Details
Published in:Cell death discovery 2017-11, Vol.3 (1), p.17071, Article 17071
Main Authors: Cassandri, Matteo, Smirnov, Artem, Novelli, Flavia, Pitolli, Consuelo, Agostini, Massimiliano, Malewicz, Michal, Melino, Gerry, Raschellà, Giuseppe
Format: Article
Language:English
Subjects:
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631/80
Actin
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cell adhesion & migration
Cell Biology
Cell Cycle Analysis
Cell migration
DNA repair
Gene regulation
Life Sciences
Proteins
Review
review-article
Ribonucleic acid
Ribose
RNA
Signal transduction
Stem Cells
Transcription
Transduction
Ubiquitin
Zinc finger proteins
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Summary:Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other proteins. Thus, ZNFs are involved in the regulation of several cellular processes. In fact, ZNFs are implicated in transcriptional regulation, ubiquitin-mediated protein degradation, signal transduction, actin targeting, DNA repair, cell migration, and numerous other processes. The aim of this review is to provide a comprehensive summary of the current state of knowledge of this class of proteins. Firstly, we describe the actual classification of ZNFs, their structure and functions. Secondly, we focus on the biological role of ZNFs in the development of organisms under normal physiological and pathological conditions.
ISSN:2058-7716
2058-7716
DOI:10.1038/cddiscovery.2017.71