A Risk Factor Analysis of Cognitive Impairment in Elderly Patients with Chronic Diseases in a Chinese Population

BACKGROUND This study analyzed the risk factors of cognitive impairment (CI) in elderly patients with chronic diseases. MATERIAL AND METHODS In total of 385 elderly patients with chronic diseases were selected and assigned into CI and normal groups. The activities of daily living (ADL), global deter...

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Bibliographic Details
Published in:Medical science monitor 2017-09, Vol.23, p.4549-4558
Main Authors: Li, Ye, Fang, Xiang, Zhao, Wei-Gang, Chen, Yan, Hu, Shi-Lian
Format: Article
Language:English
Subjects:
Activities of Daily Living
Age Factors
Aged
Aged, 80 and over
China
Chronic Disease
Clinical Research
Cognition
Cognition Disorders - complications
Cognitive Dysfunction - etiology
Cognitive Dysfunction - metabolism
Cognitive Dysfunction - psychology
Factor Analysis, Statistical
Female
Humans
Logistic Models
Male
Neuropsychological Tests
Risk Factors
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Summary:BACKGROUND This study analyzed the risk factors of cognitive impairment (CI) in elderly patients with chronic diseases. MATERIAL AND METHODS In total of 385 elderly patients with chronic diseases were selected and assigned into CI and normal groups. The activities of daily living (ADL), global deterioration scale (GDS), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA), patient-generated subjective global assessment (PG-SGA), and mini nutritional assessment (MNA) were performed to analyze the differences between the 2 groups. Logistic regression analysis was conducted for risk factors of CI in elderly patients with chronic diseases. RESULTS There were differences in age, education level, type 2 diabetes mellitus, multifocal cerebral infarction, hearing, and eyesight between CI and normal groups. Patients in the CI group showed more CD4+ cells, more admission times, and higher GDS scores than the normal group. Also, MMSE and MoCA scores revealed differences in total score, directive force, attention and calculating ability, language, delayed memory, reading comprehension, writing, and visual-spatial ability between the 2 groups. The number of B and CD8+ cells, ADL, and MNA scores were protective factors, while cerebral infarction history, number of CD4+ cells, admission times, GDS score, and age were risk factors of CI in elderly patients with chronic diseases. CONCLUSIONS Our study provides evidence that cerebral infarction history, number of CD4+ cells, admission times, GDS score, and age are risk factors of CI in elderly patients with chronic diseases.
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.904254