Low-intensity pulsed ultrasound improves behavioral and histological outcomes after experimental traumatic brain injury

The purpose of this study was to investigate the neuroprotective effects of low-intensity pulsed ultrasound (LIPUS) on behavioral and histological outcomes in a mouse model of traumatic brain injury (TBI). Mice subjected to controlled cortical impact injury were treated with LIPUS in the injured reg...

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Bibliographic Details
Published in:Scientific reports 2017-11, Vol.7 (1), p.15524-10, Article 15524
Main Authors: Su, Wei-Shen, Wu, Chun-Hu, Chen, Szu-Fu, Yang, Feng-Yi
Format: Article
Language:English
Subjects:
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Blood-brain barrier
Cortex
Edema
Humanities and Social Sciences
Magnetic resonance imaging
Membrane permeability
multidisciplinary
Neurodegeneration
Neuroimaging
Neuroprotection
Permeability
Recovery of function
Science
Science (multidisciplinary)
Statistical analysis
Traumatic brain injury
Ultrasonic imaging
Ultrasound
Water content
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Summary:The purpose of this study was to investigate the neuroprotective effects of low-intensity pulsed ultrasound (LIPUS) on behavioral and histological outcomes in a mouse model of traumatic brain injury (TBI). Mice subjected to controlled cortical impact injury were treated with LIPUS in the injured region daily for a period of 4 weeks. The effects of LIPUS on edema were observed by MR imaging in the mouse brain at 1 and 4 days following TBI. Brain water content, blood-brain barrier permeability, histology analysis, and behavioral studies were performed to assess the effects of LIPUS. Two-way analysis of variance and Student t test were used for statistical analyses, with a significant level of 0.05. Treatment with LIPUS significantly attenuated brain edema, blood-brain barrier permeability, and neuronal degeneration beginning at day 1. Compared with the TBI group, LIPUS also significantly improved functional recovery and reduced contusion volumes up to post-injury day 28. Post-injury LIPUS treatment reduced brain edema and improved behavioral and histological outcomes following TBI. The neuroprotective effects of LIPUS may be a promising new technique for treating TBI.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-15916-2