Caenorhabditis elegans as an Emerging Model for Virus-Host Interactions

Since 1999, has been extensively used to study microbe-host interactions due to its simple culture, genetic tractability, and susceptibility to numerous bacterial and fungal pathogens. In contrast, virus studies have been hampered by a lack of convenient virus infection models in nematodes. The rece...

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Bibliographic Details
Published in:Journal of virology 2017-12, Vol.91 (23)
Main Author: Gammon, Don B
Format: Article
Language:English
Subjects:
Animals
Caenorhabditis elegans - immunology
Caenorhabditis elegans - virology
Gem
Host-Pathogen Interactions
Immunity, Innate
Models, Animal
Nodaviridae - physiology
RNA Interference
RNA Viruses - immunology
RNA Viruses - physiology
Vesiculovirus - physiology
Virus Diseases - immunology
Virus Diseases - virology
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Summary:Since 1999, has been extensively used to study microbe-host interactions due to its simple culture, genetic tractability, and susceptibility to numerous bacterial and fungal pathogens. In contrast, virus studies have been hampered by a lack of convenient virus infection models in nematodes. The recent discovery of a natural viral pathogen of and development of diverse artificial infection models are providing new opportunities to explore virus-host interplay in this powerful model organism.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00509-17