Proteome-based identification of apolipoprotein A-IV as an early diagnostic biomarker in liver fibrosis

Hepatic fibrosis may ultimately result in organ failure and death, a reality compounded by the fact that most drugs for liver fibrosis appear to be effective only if given as a prophylactic or early treatment. In a dimethylnitrosamine-induced liver fibrotic model, aspartate aminotransferase/alanine...

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Published in:Oncotarget 2017-10, Vol.8 (51), p.88951-88964
Main Authors: Wang, Pei-Wen, Hung, Yu-Ching, Wu, Tung-Ho, Chen, Mu-Hong, Yeh, Chau-Ting, Pan, Tai-Long
Format: Article
Language:English
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Research Paper
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Summary:Hepatic fibrosis may ultimately result in organ failure and death, a reality compounded by the fact that most drugs for liver fibrosis appear to be effective only if given as a prophylactic or early treatment. In a dimethylnitrosamine-induced liver fibrotic model, aspartate aminotransferase/alanine aminotransferase levels could not precisely distinguish the differences between the initial stage of liver fibrosis and normal control, whereas histological examination indicated that dimethylnitrosamine treatment for two weeks has resulted in hepatic fibrogenesis. Comprehensive proteomics identified 12 proteins mainly associated with the interleukin 6-stimulated inflammatory pathway. Coordinately, cytokine profiles showed that dimethylnitrosamine administration would stimulate various signaling pathways leading to liver fibrosis. Of note, apolipoprotein A4 in serum samples obtained from patients in the early stage of liver fibrosis were significantly increased compared to the healthy controls (
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.21627