Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density

Temporal and spatial variations in bone marrow adipose tissue (MAT) can be indicative of several pathologies and confound current methods of assessing immediate changes in bone mineral remodeling. We present a novel dual-energy computed tomography (DECT) method to monitor MAT and marrow-corrected vo...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2017-07, Vol.35 (4), p.428-436
Main Authors: Arentsen, Luke, Hansen, Karen E., Yagi, Masashi, Takahashi, Yutaka, Shanley, Ryan, McArthur, Angela, Bolan, Patrick, Magome, Taiki, Yee, Douglas, Froelich, Jerry, Hui, Susanta K.
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - diagnostic imaging
Adiposity
Adult
Aged
Aged, 80 and over
Bone composition
Bone Density - physiology
Bone marrow
Bone Marrow - diagnostic imaging
Bone mineral density
Bone remodeling
Cadaver
Cadavers
Cancellous bone
Cancellous Bone - diagnostic imaging
Cancellous Bone - physiology
Computed tomography
Female
Humans
Humerus
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Original Article
Orthopedics
Skeleton
Skull
Spatial variations
Spine
Tomography
Tomography, X-Ray Computed - methods
Vertebrae
X-Ray Microtomography
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Summary:Temporal and spatial variations in bone marrow adipose tissue (MAT) can be indicative of several pathologies and confound current methods of assessing immediate changes in bone mineral remodeling. We present a novel dual-energy computed tomography (DECT) method to monitor MAT and marrow-corrected volumetric BMD (mcvBMD) throughout the body. Twenty-three cancellous skeletal sites in 20 adult female cadavers aged 40–80 years old were measured using DECT (80 and 140 kVp). vBMD was simultaneous recorded using QCT. MAT was further sampled using MRI. Thirteen lumbar vertebrae were then excised from the MRI-imaged donors and examined by microCT. After MAT correction throughout the skeleton, significant differences ( p  
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-016-0796-1