Homocysteine in retinal artery occlusive disease: A meta-analysis of cohort studies

Few studies have reported the relationship between retinal artery occlusion (RAO) and plasma homocysteine (Hcy) levels. Our goal was to evaluate the association between the plasma Hcy level and the risk of RAO disease. Several databases were searched for all published studies that involved Hcy and R...

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Bibliographic Details
Published in:Scientific reports 2017-11, Vol.7 (1), p.15708-8, Article 15708
Main Authors: Huang, Xuetao, Yang, Yezhen, Duan, Yiqin, Kuang, Yi-Qun, Lin, Ding
Format: Article
Language:English
Subjects:
692/699
692/699/3161
Cohort analysis
Health risk assessment
Homocysteine
Humanities and Social Sciences
Hyperhomocysteinemia
Meta-analysis
multidisciplinary
Occlusion
Retina
Science
Science (multidisciplinary)
Studies
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Summary:Few studies have reported the relationship between retinal artery occlusion (RAO) and plasma homocysteine (Hcy) levels. Our goal was to evaluate the association between the plasma Hcy level and the risk of RAO disease. Several databases were searched for all published studies that involved Hcy and RAO. Six studies evaluated hyperhomocysteinemia (hHcy) in retinal artery occlusion patients and controls; the incidence of hHcy in patients with RAO was higher than the control and the pooled odds ratio (OR) was 6.64 (95% confidence interval (CI): 3.42, 12.89). Subgroup analyses showed that the ORs were 4.77 (95% CI: 2.69, 8.46) in Western countries, 22.19 (95% CI: 2.46, 200.37) in Asian countries, 9.70 (95% CI: 4.43, 21.20) in the age matched group, 11.41 (95% CI: 3.32, 39.18) in the sex matched group, 9.70 (95% CI: 4.37, 21.53) in the healthy control group, and 6.82 (95% CI: 4.19, 11.10) in the sample size >30. The mean plasma Hcy level from 5 case-control studies was higher than controls, and the weighted mean difference (WMD) was 6.54 (95% CI: 2.79, 10.29). Retinal artery occlusion is associated with elevated plasma Hcy levels. Our study results suggest that hHcy is probably an independent risk factor for RAO.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-16065-2