Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy

A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal col...

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Bibliographic Details
Published in:Scientific reports 2017-11, Vol.7 (1), p.15750-12, Article 15750
Main Authors: Bigliardi, Paul Lorenz, Rout, Bhimsen, Pant, Aakanksha, Krishnan-Kutty, Viknish, Eberle, Alex N., Srinivas, Ramasamy, Burkett, Brendan Adrian, Bigliardi-Qi, Mei
Format: Article
Language:English
Subjects:
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Cytotoxicity
Humanities and Social Sciences
Hyperpigmentation
Keratinocytes
Malignancy
Melanocortin
Melanocyte-stimulating hormone
Melanocytes
Melanoma
multidisciplinary
Photodynamic therapy
Science
Science (multidisciplinary)
Skin
Wavelengths
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Summary:A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially effective adjuvant therapeutic method to control benign skin hyperpigmentation or superficial melanotic malignancy such as Lentigo Maligna Melanoma (LMM).
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-15142-w