Nutrient sensing and TOR signaling in yeast and mammals

Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR) is implicated in several di...

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Bibliographic Details
Published in:The EMBO journal 2017-02, Vol.36 (4), p.397-408
Main Authors: González, Asier, Hall, Michael N
Format: Article
Language:English
Subjects:
Amino acids
Animals
Cell growth
Cell Proliferation
EMBO21
EMBO37
Energy Metabolism
Food
glucose
Mammals
Mammals - physiology
Nutrient availability
nutrients
RAG
Review
Saccharomyces cerevisiae - physiology
Signal Transduction
TOR Serine-Threonine Kinases - metabolism
TORC1
Yeast
Yeasts
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Summary:Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR) is implicated in several disorders, including cancer, obesity, and diabetes. Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR‐related diseases. Graphical Abstract As part of our metabolism focus, this review summarizes how nutrient availability is recognized and integrated by the conserved TOR cell growth regulator.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.201696010