Successful downstaging of locally recurrent penile squamous cell carcinoma with neoadjuvant nanosomal docetaxel lipid suspension (NDLS) based regimen followed by curative surgery

Penile squamous cell carcinoma (pSCC) is a relatively rare disease in Western world but is a significant health problem in developing countries like India. We report here a case of successful multimodality management of recurrent pSCC with pelvic lymphadenopathy in a 56-year-old male patient with po...

Full description

Saved in:
Bibliographic Details
Published in:BMJ case reports 2017-11, Vol.2017, p.bcr-2017-220686
Main Authors: Gupta, Sameer, Pawar, Shashi Singh, Bunger, Deepak
Format: Article
Language:English
Subjects:
Asia
Biopsy
Breast cancer
Cancer therapies
Case reports
Chemotherapy
Diabetes
Dissection
Genital cancers
Head & neck cancer
Indian Sub-Continent
Lipids
Lymphatic system
Male
Metastasis
Novel Treatment (New Drug/Intervention
Established Drug/Procedure in New Situation)
Pain
Patients
Penis
Response rates
Squamous cell carcinoma
Surgery
Urological cancer
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Penile squamous cell carcinoma (pSCC) is a relatively rare disease in Western world but is a significant health problem in developing countries like India. We report here a case of successful multimodality management of recurrent pSCC with pelvic lymphadenopathy in a 56-year-old male patient with poorly controlled diabetes. The patient presented with ulceroproliferative growth over the residual penile stump clinically involving root of penis and with right pelvic lymphadenopathy. The patient had a history of partial penectomy done elsewhere 20 months ago. In view of the comorbidities, locally recurrent disease and presence of right Iliac lymphadenopathy, the patient was treated with nanosomal docetaxel lipid suspension (NDLS), cisplatin and 5-fluorouracil (TPF regimen) in the neoadjuvant setting followed by staged surgical resection. This is the first case report showing successful treatment of recurrent pSCC with NDLS-based TPF regimen in the neoadjuvant setting followed by staged surgery in a patient with poorly controlled diabetes.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2017-220686